
Prior to her professional acting career, Miller worked as a photographic model. She currently models for Pepe Jeans, and she posed for Vanity Fair magazine's 2006 Hollywood Issue topless and smoking a cigarette. Sienna Rose Miller was born in New York City. She moved to England as a child and attended the Heathfield school in Ascot, Berkshire and later studied for a year at the Lee Strasberg Institute in New York City. She had a recurring role in the television series
Keen Eddie. Miller appeared in supporting roles in the 2004 remake of the 1966 movie
Alfie as well as in
Layer Cake (2004). She played the female lead opposite Heath Ledger in the period drama,
Casanova (2005).
With the upsides of fames, there are also downsides, and Sienna was a constant target for press scrutiny/malicious gossip/slandering. Numerous stories were printed about her relationship with Jude being over, amongst other things, and this led Sienna to threaten to leave Britian, and she spoke of her dislike of the press attention - "I don't know why newspapers and magazines gravitate towards slander. It just seems they're constantly out to invent. It has come about as a result of a relationship I didn't plan. And of course I would be naive to think it wouldn't happen if I hadn't got together with Jude. But I got Alfie of my own accord. I take my job very seriously." Despite all of this, Sienna spent the months leading up to June rehearsing for As You Like It in London. When asked about why she wanted to take this role, she said “Hopefully I’ll be taken more seriously as an actress than whatever else...“I’m doing this for myself and for the experience of doing a play."
When As You Like It opened in June 2005, reactions were mixed. Some reviews were less than complimentary of Sienna's performance, however, others raved that she was the star of the show and a real revelation. The critics really couldn't do anything but praise Sienna when she bravely took on the role of Rosalind when Helen McRory fell ill. Sienna received a standing ovation and one audience member said Sienna "...was absolutely amazing. I swear I was crying by the end." Director David Lan added "I was astonished. There was absolutely no reason why Sienna should know a single line." Sienna was more modest though - "You must come back and see Helen in the role, she's much better than me" and later revealed she was "not completely conscious of what just happened. I've felt in a complete state of shock and in a way I still am. I just attempted to imitate Helen McCrory."
In November Sienna started filming for "Factory Girl" in which she played Edie Sedgwick. The film also starred Hayden Christensen and Guy Pearce.With Factory Girl finished in early 2006, Sienna took a short break before moving on to her next project - Interview - in which she plays 'the most popular soap star in America' alongside 'fading political journalist' Steven Buscemi (who also took the role of director). Sienna then re-teamed with her Layer Cake director, Matthew vaughn, to shoot the fairytale-esque Stardust in May, in Wiltshire (England). Co-starring in this were two very big names - Michelle Pfeiffer and Robert DeNiro, alongside Clare Danes and Sienna's friend and on-screen-in- Casanova-brother Charlie Cox. Interview and Stardust were fairly short shoots. They were followed by the black romantic comedy Camille, which was shot in Toronto in July/August of the same year. The tabloids flared up with stories of Sienna's romantic relationship with her co-star James Franco, which Sienna toke in her stride and denied.

In 2008, Miller appeared in the film version of writer Michael Chabon's novel,
The Mysteries of Pittsburgh" also starring Peter Saarsgard and filmed
The Edge of Love, with friend Keira Knightley, a biopic of Dylan Thomas in which she plays his wife Caitlan.
She appears in two upcoming films:
Hippie Hippie Shake directed by Beeban Kidron also stars Cillian Murphy set in the 1960s, and a live-action film adaptation of the comic book and cartoon G.I Joe. In September 2009 she will play the title role in Patrick Marber's
After Miss Julie on Broadway.
Miller was set to play Maid Marian in Ridley Scott's upcoming film
Nottingham, featuring Russell Crowe as the Sheriff of Nottingham. However, she was removed from the role before filming began.
Sienna is also an accomplished fashion designer. Alongside with her sister Savannah, they created Twenty8Twelve. The name coming from Sienna's date of birth.